![]() Planning and execution of immunogenicity studies of conjugate vaccines in mice and rat models.Skilled in various analytical techniques like HPLC, spectrophotometry, karl fischer titration for moisture, electrophoretic assays like SDS-PAGE, Western blot.Skilled in analysis of polysaccharide vaccines by high performance anion exchange chromatography - pulse amperometric detection (HPAEC-PAD).Development of HPLC process and other analytical techniques for qualification and quantification of polysaccharide based vaccines.Experience in carrying out manufacturing operations under GMP environment.Operation of continuous centrifuge and ultracentrifuge.Experience in operation of wave bioreactors.(Chemap), 75 liter (Scigenics), 500 Liter (Scigenics) Experience in fermenter operation at various scales 5 liter (Sartorius), 20 Liter.Worked on bacterial fermentations and animal cell culture techniques.Optimization and scale up of fermentation process Experience in small scale and large scale fermenter operations.PRIME (GE), AKTA PROCESSOR (GE) and K-PRIME (Millipore) Adept at handling different chromatography systems like AKTA AVANT (GE), AKTA.Packing and evaluation of chromatography columns: XK and BPG columns (GE) vantage, moduline and quick scale columns (Millipore).Experience in various chromatography separation methods like affinity chromatography, ion-exchange chromatography, hydrophobic interaction chromatography and size exclusion chromatography.Experience in development of various chemistries for preparing polysaccharide- protein conjugate vaccines to generate efficient antigenic vaccine candidate.Skilled in Bioprocess Operations with ability to work on manufacturing of bio- therapeutics/vaccines and Process- and analytical- developments for biomolecules.
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